Correlation between protein expression of FOXP3 and level of FOXP3 promoter methylation in recurrent spontaneous abortion
نویسندگان
چکیده
منابع مشابه
Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population
Unexplained recurrent spontaneous abortion (URSA) is an alloimmune disease associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Treg) play a pivotal role. It is well known that Forkhead box P3 (Foxp3) is a crucial regulatory factor for the development and function of Treg cells. It has also been established that deficiency of the Foxp3 gene ...
متن کاملAssociation between HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion
Introduction: Recurrent spontaneous abortion is defined as the occurrence of more than two clinical miscarriages in one woman. Several factors, including endocrine irregularities, genetics and environmental factors, are involved in this kind of infertility.The aim of this study was to survey the association of HOXA10 (rs267601473) polymorphism with the risk of recurrent spontaneous abortion in ...
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Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...
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Abortion is a term used for missing of fetus before 20th week of pregnancy, which is a common complication of pregnancy and its aetiology usually remains unknown. Known aetiologies for this phenomenon include structural malformation of uterus, genetic anomalies, autoimmune conditions, endocrine defects, coagulative and trombophilic disorders, polycystic ovary, obesity, and lifestyle. Abortion h...
متن کاملP-157: TLR5 Gene Expression in Endometrium of Women with Unexplained Recurrent Spontaneous Abortion
Background: Recurrent spontaneous abortion (RSA) is usually defined as three or more consecutive pregnancy losses before 20th week of gestation. Although different factors are considered as etiology of RSA but in some cases, despite of extensive work up, the cause of RSA remains unknown which called unexplained RSA. Immunological factors are suggested as etiological factors of unexplained RSA. ...
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ژورنال
عنوان ژورنال: Journal of Obstetrics and Gynaecology Research
سال: 2016
ISSN: 1341-8076
DOI: 10.1111/jog.13076